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Complete remission in plasma cell leukaemia
Author(s) -
Montecucco Carlomaurizio,
Riccardi Alberto,
Merlini Giampaolo,
Ascari Edoardo
Publication year - 1986
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1986.tb02964.x
Subject(s) - complete remission , medicine , spontaneous remission , leukemia , plasma cell , cancer research , oncology , chemotherapy , pathology , bone marrow , alternative medicine
S ummary . Two patients with primary plasma cell leukaemia who achieved complete remission are reported. They were treated with induction therapy consisting of a multipeptide derivative of sarcolysin, Peptichemio, given intravenously, combined with vincristine and/or prednisone, followed by conventional melphalan‐prednisone therapy. 5–7 months following the beginning of therapy, both patients attained a complete remission which lasted 23 and 6 months; second remission was not achieved. Survival from starting therapy was 57 and 16 months respectively. These cases indicate that intravenous alkylating agents can induce a complete remission in plasma cell leukaemia similar to that achieved in other acute leukaemias.