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Natural killer cell activity following T‐cell depleted allogeneic bone marrow transplantation
Author(s) -
Rooney C. M.,
Wimperis J. Z.,
Brenner M. K.,
Patterson J.,
Hoffbrand A. V.,
Prentice H. G.
Publication year - 1986
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1986.tb02952.x
Subject(s) - immunology , transplantation , bone marrow , natural killer cell , t cell , cell , medicine , lymphokine activated killer cell , biology , interleukin 21 , immune system , cytotoxic t cell , in vitro , biochemistry , genetics
S ummary . We have examined the recovery of natural killer (NK) cell function in seven recipients of MHC matched T cell depleted bone marrow allografts. NK cell activity against the erythroblastoid line K562 recovers 2–3 weeks after transplantation. Recipients also show a high level of killing of the T cell target HSB2 and of EBV transformed lymphoblastoid cell lines (B‐LCL). This activity peaks at 4–6 weeks and declines towards normal by 12–14 weeks after transplantation. Although killing of HSB2 and B‐LCL is usually the property of activated NK cells, few of these patients had any obvious ‘trigger’ of such activation: none had CMV infection, there were no episodes of graft rejection, and only two patients had mild and transient grade I graft versus host disease (GvHD). We conclude that T cell depletion does not affect the reconstitution of NK cell function and that NK cell activation occurs after T depleted bone marrow transplantation even in the absence of clinically detectable GvHD, graft rejection or CMV infection.