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Influence of graft‐versus‐host disease prophylaxis on early T‐lymphocyte regeneration following allogeneic bone marrow transplantation
Author(s) -
Gratama J. W.,
Würsch A. M.,
Nissen C.,
Gratwohl A.,
D'Amaro J.,
Gast G. C.,
Rood J. J.,
Speck B.
Publication year - 1986
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1986.tb02939.x
Subject(s) - methotrexate , repopulation , medicine , immunology , lymphocyte , bone marrow , transplantation , graft versus host disease , regeneration (biology) , t lymphocyte , bone marrow transplantation , gastroenterology , antigen , biology , stem cell , haematopoiesis , genetics , microbiology and biotechnology
S ummary . An early decrease in the ratio between T4 + and T8 + T lymphocytes has been shown to correlate with the development of grade II‐IV GVHD in allogeneic bone marrow transplant (BMT) recipients receiving methotrexate (MTX) as prophylaxis for acute graft‐versus‐host disease (GVHD). This study compares the onset of T‐cell regeneration in patients receiving cyclosporin A (CyA) with those receiving MTX. Firstly, lymphoid recovery occurred at a significantly faster rate in the patients on CyA. Secondly, in those patients, the repopulation of T4+ and T8+ T cells started simultaneously, whereas in patients on MTX the repopulation of the T8+ subset lagged about a week behind that of the T4+ subset. Thirdly, the decrease in the T4/T8 ratios as a function of the lymphocyte counts occurred at a significantly slower rate in the patients on CyA than in those on MTX. Thus, the differences in the onset of T‐cell regeneration in BMT recipients on CyA as compared with those on MTX abolished the correlation of the T4/T8 ratio changes with grades II‐IV GVHD as described in patients receiving MTX.