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Changes in fluidity and composition of erythrocyte membranes and in composition of plasma lipids in Type I diabetes
Author(s) -
Bryszewska Maria,
Watala Cezary,
Torzecka Wieslawa
Publication year - 1986
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1986.tb02906.x
Subject(s) - microviscosity , phospholipid , membrane , membrane fluidity , cholesterol , composition (language) , chemistry , erythrocyte membrane , diabetes mellitus , endocrinology , biochemistry , medicine , biology , philosophy , linguistics
S ummary . Changes in the fluidity and composition of human erythrocyte membranes and in the composition of plasma in Type I (insulin‐dependent) diabetes were investigated. The increased microviscosity of diabetic erythrocyte membranes provide unambiguous proof of the structural deterioration of erythrocyte membranes in diabetes. It seems most likely that enhancement of the membrane cholesterol/phospholipid ratio is the main reason for decreased membrane fluidity in diabetes. A distinct correlation between membrane cholesterol/phospholipid ratio, plasma cholesterol content and membrane fluidity was found. Composition and structural changes in erythrocyte membranes and compositional changes in plasma lipids may contribute to the development of diabetic complications in diabetes.