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Certain myeloid cells possess receptors for interleukin‐2
Author(s) -
Armitage R. J.,
Lai A. P.,
Roberts P. J.,
Cawley J. C.
Publication year - 1986
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1986.tb02242.x
Subject(s) - promyelocyte , receptor , stimulation , in vitro , monoclonal antibody , immunology , biology , microbiology and biotechnology , myeloid , antibody , endocrinology , biochemistry
S ummary . A proportion of blasts from five of 10 cases of AML expressed receptors for IL‐2 (IL‐2R) when tested directly ex‐vivo with monoclonal antibodies against the receptor. After in‐vitro stimulation with various agents including TPA, γ interferon and colony stimulating factor, the purified blast cells of all cases of AML tested (10 of 10) showed high levels (50–90% cells positive) of IL‐2R expression. Granulocytic cells from the promyelocyte stage onwards lacked IL‐2R both before and after in‐vitro stimulation. In contrast, leukaemic promonocytes and normal peripheral monocytes expressed IL‐2R both before and after stimulation.