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Variant translocation t(8;22) and abnormalities of chromosome 15(q22) and 17(q 12–21) in a Burkitt's lymphoma/leukaemia with disseminated intravascular coagulation
Author(s) -
Daly Peter,
BritoBabapulle Vasantha,
Lawlor Emer,
Blaney Claire,
Parreira Antonio,
Catovsky Daniel
Publication year - 1986
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1986.tb02212.x
Subject(s) - chromosomal translocation , disseminated intravascular coagulation , lymphoma , pathology , breakpoint , bone marrow , medicine , immunology , biology , gene , genetics
S ummary . Severe disseminated intravascular coagulation was observed in a patient with Burkitt's lymphoma/leukaemia. Immunological studies on leukae‐mic blasts from relapsed bone marrow revealed a B‐cell phenotype (B4+. B1+, HLA‐ Dr+, J5+) with membrane bound IgMλ Cytogenetic investigation revealed a variant Burkitt's translocation t(8;22)(q24;q11) involving the λ light chain gene region and abnormalities of chromosomes 15 and 17 with breakpoints at q22 and q 12 respectively, similar to those observed in the t(15:17) in acute promyelocytic leukaemia. Transmission electron microscopy of the leukaemic blasts showed crystalline cytoplasmic inclusions which may have had a role in precipitating the disseminated intravascular coagulation.