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Suppression of clonal evolution in two chronic myelogenous leukaemia patients treated with leucocyte interferon
Author(s) -
Talpaz M.,
Trujillo J. M.,
Hittelman W. N.,
Keating M. J.,
Gutterman J. U.
Publication year - 1985
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1985.tb07464.x
Subject(s) - clone (java method) , blast crisis , bone marrow , population , interferon , immunology , philadelphia chromosome , chronic myelogenous leukemia , somatic evolution in cancer , biology , medicine , cancer research , leukemia , chromosomal translocation , genetics , dna , gene , cancer , environmental health
S ummary Two patients with Philadelphia chromosome‐positive (Ph1 +) chronic myelogenous leukaemia (CML) were treated with human leucocyte interferon (HuIFN‐ α ). Karyotypic changes in addition to the Ph1 chromosome developed in these patients before the start of HuIFN‐ α treatment. In one patient the administration of HuIFN‐ α resulted in clinical haematological remission and stable suppression of the secondary Ph1 clone. The second patient was in myeloid blastic crisis when given HuIFN‐ α . While she was receiving HuIFN‐ α , suppression of the blast cell population in the bone marrow occurred. The subsequent cytogenetic changes included a near‐complete suppression of a secondary Ph1 clone of cells carrying a deletion in the short arm of chromosome 7 and partial population of the bone marrow with primary Ph1 clone. These observations suggest a potential role for interferons in altering the progressive course of CML.