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Cyclosporine and graft failure following bone marrow transplantation for severe aplastic anaemia
Author(s) -
Hows J.,
P almer S.,
GordonSmith E. C.
Publication year - 1985
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1985.tb07463.x
Subject(s) - medicine , surgery , complication , incidence (geometry) , bone marrow failure , bone marrow , aplastic anemia , transplantation , haematopoiesis , stem cell , physics , biology , optics , genetics
S ummary Thirty‐nine patients with severe aplastic anaemia were transplanted from HLA identical sibling donors. Irradiation was not used in the pre‐transplant immunosuppressive protocol and cyclosporine was used as the post graft immuno‐suppressive agent. The incidence of primary graft failure (no take) was low occurring in 3/38 evaluable patients. Late graft failure 4–7.5 months post BMT occurred in five patients and was associated with withdrawal of cyclosporine therapy. Mixed lymphocyte chimaerism was demonstrated in 3/5 cases at the time of late graft failure and subsequent marrow recovery was autologous in four patients. Mortality from graft failure was low with 2/38 evaluable patients (5%) dying from this complication.