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Leukaemic transformation of engrafted bone marrow cells
Author(s) -
Smith Janice L.,
Heerema Nyla A.,
Provisor Arthur J.
Publication year - 1985
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1985.tb07438.x
Subject(s) - bone marrow , karyotype , medicine , bone marrow transplantation , pathology , transplantation , malignant transformation , cytogenetics , leukemia , immunology , biology , genetics , chromosome , gene
S ummary Recurrent leukaemia following bone marrow transplantation is most often due to the regrowth of original host leukaemia cells, but may also be due to the malignant transformation of normal donor marrow cells after transplantation into a leukaemia patient. We report the ninth case of malignant change in cells of donor origin in a 12‐year‐old boy who was originally diagnosed as having Ph 1 + CML. He remained Ph 1 + during lymphoid blast crisis. After transplantation with marrow from a cytogenetically normal sister, he relapsed to Ph 1 – ALL in the female donor cells. The marrow showed a mixed karyotype of 46,XX/46,XX,inv(9)(p12q12). It would appear that, haematologically, the patient showed different manifestations of the same disease state. Cytogenetically, however, the pre‐ and post‐transplant leukaemias were different.