Premium
Standardization of prekallikrein activator (PKA): the 1st International Standard for PKA
Author(s) -
Kerry P. J.,
Curtis A. D.,
Thomas D. P.
Publication year - 1985
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1985.tb07420.x
Subject(s) - activator (genetics) , standardization , potency , international standardization , chemistry , political science , biochemistry , law , in vitro , gene
S ummary A international collaborative study was carried out to establish an international standard for prekallikrein activator (PKA). The candidate material, coded 82/530, was assayed against the Office of Biologics (FDA) PKA reference preparation No. 2 (OoB 2) and the 1st British Reference Preparation for PKA. There was good agreement between participant laboratories on the relative PKA activity of the three preparations. Preparation 82/530 has been established by the World Health Organization as the 1st I.S. for PKA, with an assigned potency of 85 International Units per ampoule.