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Colony formation by primitive haemopoietic progenitors in cocultures of bone marrow cells and stromal cells
Author(s) -
Gordon M. Y.,
Hibbin J. A.,
Kearney L. U.,
GordonSmith E. C.,
Goldman J. M.
Publication year - 1985
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1985.tb07393.x
Subject(s) - progenitor cell , bone marrow , stromal cell , peripheral blood mononuclear cell , biology , microbiology and biotechnology , stem cell , immunology , in vitro , cancer research , genetics
S ummary Human bone marrow contains a class of human haemopoietic progenitor cells that adhere to cultured marrow stromal cells and form colonies of blast cells. These progenitor cells are found in the non‐adherent mononuclear fraction of normal human bone marrow. They are not in active cell cycle and do not express Ia‐like (HLA‐DR) antigens but appear to be capable of self‐renewal in vitro . These properties indicate that they should be classified as members of the primitive haemopoietic progenitor cell compartment.