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The kinetics of unmatched and HLA‐matched 111 In‐labelled homologous platelets in recipients with chronic marrow hypoplasia and anti‐platelet immunity
Author(s) -
Peters A. M.,
Porter J. B.,
Saverymuttu S. H.,
Malik F.,
Zuiable A.,
Lavender J. P.,
Schwarz G.,
Lewis S. M.,
GordonSmith E. C.
Publication year - 1985
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1985.tb07392.x
Subject(s) - platelet , human leukocyte antigen , immunology , refractory (planetary science) , medicine , homologous chromosome , kinetics , gastroenterology , antigen , chemistry , biology , biochemistry , physics , quantum mechanics , astrobiology , gene
S ummary The kinetics of homologous platelets, labelled in plasma with 111 In‐tropolonate, have been studied in five recipients with chronic marrow hypoplasia and severe thrombocytopenia, who were refractory to platelet transfusions as a result of alloimmunization. Mean platelet life span (MPLS), recovery, plasma 111 In level and splenic and hepatic uptake kinetics were studied on two occasions, one using HLA‐matched platelets and the other unmatched platelets. In each case, recovery of labelled platelets at 1 h post‐injection and MPLS improved with HLA matching, although this improvement was highly variable. Only two of the five subjects would have derived any significant benefit from HLA‐matched as compared with unmatched platelet transfusions. It was concluded that the need exists for additional cross‐matching procedures, possibly related to platelet specific antigens, in patients who remain refractory to platelet transfusion.