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Transient expression of a second monoclonal component in two forms of biclonal gammopathy
Author(s) -
Bast E. J. E. G.,
SlaperCortenbach C. M.,
Verdonck L. F.,
Samson W.,
Ballieux R. E.
Publication year - 1985
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1985.tb07389.x
Subject(s) - monoclonal gammopathy , idiotype , monoclonal antibody , kappa , monoclonal , clone (java method) , paraproteinemias , gammopathy , microbiology and biotechnology , medicine , antibody , chemistry , immunology , biology , gene , biochemistry , philosophy , linguistics
S ummary Two cases of transient biclonal gammopathy are described, one having an IgG K and an IgA K monoclonal component and another with IgG1 K and IgG K monoclonal components. In both of these cases the second monoclonal component gradually disappeared. Anti‐idiotypic antibodies were made against the major monoclonal serum component; in the first case the idiotype of the IgG K clone was not found in the IgA K plasma cells (real biclonal gammopathy) whereas in the second case the idiotypes of the two clones were identical (apparent biclonal gammopathy). The evolution to monoclonal gammopathy is discussed with regard to the existence of common malignant precursor cells in biclonal gammopathy.