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Platelet associated complement components (PAC 3c and PAC 3d ) in patients with autoimmune thrombocytopenia
Author(s) -
Hegde U. M.,
Bowes A.,
Roter B. L. T.
Publication year - 1985
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1985.tb07384.x
Subject(s) - autoimmune thrombocytopenia , platelet , antibody , immunology , medicine , complement system
S ummary Platelet associated C 3c and C 3d (PAC 3c and PAC 3d ) were quantitated by enzyme linked assay in 105 patients with idiopathic autoimmune thrombocytopenia (AITP) in whom elevated platelet associated immunoglobulins (IgG and IgM) had previously been documented. Increased levels of complement components were demonstrated in 46 of 105 patients (43.8%). In 11 of these patients, PAC 3d alone was abnormal implying that C 3b had been inactivated after cleavage by C 3 inactivator in vivo . Complement binding was seen in two of 16 patients (12.5%) with raised PAIgG alone, four of 19 patients (21.0%) with raised PAIgM alone and in 40 of 70 patients (57.1%) in whom PAIgG and PAIgM were raised together. This difference was highly significant ( P = 0.01). The clinical implication of these findings are discussed.