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Lymphoid crisis with T‐cell phenotypes in a patient with Philadelphia chromosome negative chronic myeloid leukaemia
Author(s) -
Soda H.,
Kuriyama K.,
Tomonaga M.,
Yao E.,
Amenomori T.,
Yoshida Y.,
Matsuo T.,
Jinnai I.,
Sadamori N.,
Ichimaru M.
Publication year - 1985
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1985.tb07362.x
Subject(s) - terminal deoxynucleotidyl transferase , myeloid , biology , microbiology and biotechnology , acid phosphatase , bone marrow , stem cell , antigen , immunology , pathology , immunohistochemistry , medicine , genetics , enzyme , biochemistry , tunel assay
S ummary A case of Philadelphia (Ph 1 ) chromosome negative chronic myeloid leukaemia (CML) developed lymphoid crisis. Immunological marker studies disclosed that the lymphoid cells were sheep erythrocyte‐rosetting ‐ , Leu‐1 + , Leu‐5 + , OKT‐4 + , OKT‐8 + , common ALL antigen ‐ , HLA‐DR ‐ , cytoplasmic and surface immunoglobulin ‐ , MAS 036C(antithymocyte) + (after in vitro culture) and terminal deoxynucleotidyl transferase ‐ , indicating T‐cell phenotypes, probably of common thymocytes. Cytochemical staining also demonstrated immature T‐cell characters: dot‐positivity for acid phosphatase and beta‐glucuronidase, and negative for acid alpha‐naphthyl acetate esterase. All bone marrow metaphases exhibited normal karyotypes. Our observation suggests that the neoplastic features of a common stem cell for myeloid and lymphoid cell lines are very similar in Ph 1 positive and negative CMLs, and that the stem cell can differentiate towards T‐lineage.