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Lactoferrin in the myeloproliferative disorders: a search for granulopoietic regulator defects
Author(s) -
Brown Ross D.,
Rickard K. A.,
Kronenberg H.
Publication year - 1985
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1985.tb07356.x
Subject(s) - granulopoiesis , myeloproliferative disorders , lactoferrin , peripheral blood mononuclear cell , granulocyte , myeloid , regulator , immunology , granulocyte colony stimulating factor , colony stimulating factor , medicine , haematopoiesis , biology , stem cell , chemotherapy , biochemistry , microbiology and biotechnology , gene , in vitro
S ummary Evidence of a defect in the negative feedback control of granulopoiesis in the myeloproliferative disorders is presented. Neutrophil release of lactoferrin, plasma lactoferrin concentration, the number of lactoferrin receptor sites on mononuclear cells and granulocyte‐monocyte colony stimulating factor (GM‐CSF) release from peripheral blood cells were determined in patients with myeloproliferative disorders and compared with normal individuals. There was a significantly (P<0.001) decreased release of lactoferrin from the neutrophils of patients with myeloproliferative disorders which could be responsible for a reduced suppression of GM‐CSF release from mononuclear cells which in turn may be responsible for the increased myeloid proliferative activity in patients with myeloproliferative disorders.