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Separation of malignant plasma cells from the bone marrow of patients with myelomatosis
Author(s) -
Ali F. M. K.,
Weetman A. P.,
May A.
Publication year - 1985
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1985.tb07328.x
Subject(s) - bone marrow , multiple myeloma , peripheral blood mononuclear cell , antiserum , medicine , pathology , secretion , peripheral blood , antibody , chemistry , immunology , biochemistry , in vitro
S ummary Complement‐mediated lysis of bone marrow cells from patients with myelomatosis using a rabbit antiserum raised against normal peripheral blood mononuclear cells was found to greatly enrich the abnormal plasma cells. Cellular morphology was good and the cells were able to synthesize and secrete paraprotein. This was found to be a quick and useful method of preparing myeloma plasma cells for further studies of their metabolic properties.