Premium
Sequential development of distinct clonal chromosome abnormalities in a patient with preleukaemia
Author(s) -
Miller Barbara A.,
Weinstein Howard J.,
Nell Marilyn,
Henkle Carol T.,
Dillon Patricia L.,
Tantravahi Ramana
Publication year - 1985
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1985.tb07327.x
Subject(s) - genetics , biology , chromosome , medicine , computational biology , evolutionary biology , gene
S ummary Preleukaemia has been identified as a clonal haemopathy in which progression to acute leukaemia involves conservation of the preleukaemic karyotype in the blast cells or the development of new abnormalities superimposed on the original clone. In this report, a case of childhood preleukaemia is presented in which two cytogenetically distinct clones developed over 2 years in a dysplastic marrow that was initially karyotypically normal. One clone with 47 chromosomes (47, XY, + 21), disappeared without therapy. Predominance of the cytogenetically abnormal clone, 45,XY,−12,−17,t(12;17)(p11;q11) was associated with the development of acute myelogenous leukaemia and myelofibrosis. The development of independent clonal abnormalities in the unstable preleukaemic marrow may occur more commonly than has been previously recognized. Implications of the progression of the karyotypic abnormalities are discussed.