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Drug induced red blood cell autoantibodies co‐developed with drug specific antibodies causing haemolytic anaemias
Author(s) -
Habibi Bahman
Publication year - 1985
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1985.tb04069.x
Subject(s) - autoantibody , antibody , hapten , drug , immunology , medicine , teniposide , antigen , red cell , red blood cell , pharmacology , chemotherapy , etoposide
S ummary . Four individuals with anti‐glafenine, anti‐latamoxef and anti‐teniposide antibodies were found to have an associated red blood cell autoantibody. The two components could be separated by selective absorption and showed distinct time course patterns. In three patients a well‐defined blood group antigen was recognized as the receptor for both auto‐ and drug specific antibodies. Similarities between this type of immune response to drugs and the well‐known hapten and carrier specificities developed in animals immunized by hapten–carrier conjugates are discussed.