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Cyclical eosinophilia: a manifestation of periodic haemopoiesis?
Author(s) -
Davies J. R.,
Geary C. G.,
Testa N. G.,
Pumphrey R. S. H.
Publication year - 1985
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1985.tb04061.x
Subject(s) - eosinophilia , eosinophil , haematopoiesis , granulocyte , immunology , medicine , bone marrow , pathology , biology , microbiology and biotechnology , stem cell , asthma
S ummary . A patient is described who has had a marked eosinophilia of unknown cause for 9 years in association with episodic facial swelling. Weekly blood counts for 8 months showed cyclical variations in eosinophils, neutrophils and monocytes (mean cycle length 35 d). Marrow culture studies showed fluctuation in the incidence of granulocyte‐macrophage colonies (GM‐CFC), and the proportion of eosinophil colonies was higher than the values reported for normals. The blood lymphocyte T4/T8 ratio was reversed, due to an increase of T8 + cells. It is suggested that this condition is a rare form of periodic haemopoiesis.