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The sequence of the A γ globin gene in a G γβ + type of hereditary persistence of fetal haemoglobin
Author(s) -
Jones R. W.,
Goodbourn S. E. Y.,
Old J. M.,
Weatherall D. J.
Publication year - 1985
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1985.tb03000.x
Subject(s) - fetal hemoglobin , physics , persistence (discontinuity) , sequence (biology) , gene , genetics , globin , fetus , type (biology) , biology , microbiology and biotechnology , pregnancy , ecology , geotechnical engineering , engineering
S ummary The sequence of the A γ globin gene from the affected chromosome of an individual heterozygous for the G γβ + type of hereditary persistence of fetal haemoglobin ( G γβ + HPFH) is reported. With two exceptions, it is identical to one of the two allelic A γ globin genes already sequenced and there is therefore no change which could explain the absence of its expression in the face of the persistent G γ globin expression which is a feature of this condition.