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( A γδβ)°‐Thalassaemia in Blacks is due to a deletion of 34 kbp of DNA
Author(s) -
Henthorn P. S.,
Smithies O.,
Nakatsuji T.,
Felice A. E.,
Gardiner M. B.,
Reese A. L.,
Huisman T. H. J.
Publication year - 1985
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1985.tb02999.x
Subject(s) - beta (programming language) , dna , genetics , restriction enzyme , gene , microbiology and biotechnology , clone (java method) , biology , globin , computer science , programming language
S ummary DNA from members of 10 Black families with conditions considered to be G γδβ)°‐thalassaemia or G γδβ)°‐HPFH were studied by using restriction enzyme analysis. One or more affected members from each family were shown to have the same deletion of 34 kbp of DNA in the human β ‐globin gene cluster. A clone spanning the deletion was isolated from the DNA of one such person and studied in detail. The deletion removed part of the A γ and all of the Ψβ, δ and β ‐globin genes and is different from the four previously identified deletions which caused a condition presently known as ( A γδβ )°‐thalassaemia.