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Basophil function in patients with chronic myelogenous leukaemia
Author(s) -
LettBrown Michael A.,
Juneja Harinder S.
Publication year - 1985
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1985.tb02875.x
Subject(s) - basophil , histamine , immunology , chronic myelogenous leukemia , medicine , intracellular , ionophore , chemistry , immunoglobulin e , calcium , endocrinology , leukemia , biochemistry , antibody
S ummary . We have compared the release of histamine from basophils isolated from six patients with chronic myelogenous leukaemia (CML) and seven normal controls. No differences were noted in the release induced by rabbit anti‐human IgE. However, basophils from CML patients released <20% of their intracellular histamine when challenged with the anaphylatoxin C5a at a concentration that caused >50% release from normal basophils. Furthermore, basophils from CML donors showed a significantly lower release in the presence of the calcium ionophore A23187. These results suggest that basophils from CML patients have an inherent defect.