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Monosomy 7 and multipotential stem cell transformation
Author(s) -
Chan L. C.,
Sheer D.,
Drysdale H. C.,
Bevan D.,
Greaves M. F.
Publication year - 1985
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1985.tb02858.x
Subject(s) - stem cell , transformation (genetics) , biology , microbiology and biotechnology , genetics , gene
S ummary . Monosomy 7 was the sole karyotypic abnormality seen in a case of biphenotypic leukaemia involving both the myeloid and lymphoid lineages and in a case of de novo ALL undergoing a phenotypic shift to acute myeloid leukaemia at relapse. These observations suggest that monosomy 7 can be associated with transformation of a common lymphoid‐myeloid progenitor cell.