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Acute biphenotypic leukaemia (myeloid and null‐ALL type) supervening in a myelodysplastic syndrome
Author(s) -
Eridani S.,
Chan L. C.,
Halil O.,
Pearson T. C.
Publication year - 1985
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1985.tb02857.x
Subject(s) - clone (java method) , precursor cell , myeloid , myelodysplastic syndromes , myeloid leukaemia
S ummary . An acute leukaemia was seen in a 72–year‐old patient with a myelodysplastic syndrome (MDS) of 14 months duration, who had been treated only with steroids. The morphological appearance of the blast cells suggested a poorly differentiated cell type. Surface marker analysis, including double staining studies, showed the coexistence of a population of null acute lymphoblastic leukaemia (ALL) blast cells together with acute myeloid leukaemia type cells. No chromosomal alterations were detected. The change from a chronic MDS to an acute leukaemia of mixed (myeloid and null ALL) type suggests either transformation of a pre‐existing abnormal clone or de novo appearance of two separate leukaemic clones.