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Rapid correction of red‐cell nucleotide abnormalities following successful renal transplantation
Author(s) -
Rejman A. S. M.,
Mansell M. A.,
Grimes A. J.,
Joekes A. M.
Publication year - 1985
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1985.tb02847.x
Subject(s) - gtp' , nad+ kinase , guanosine , transplantation , nucleotide , guanosine triphosphate , adenosine triphosphate , inosine , creatinine , red cell , chemistry , medicine , endocrinology , guanosine diphosphate , biochemistry , adenosine , enzyme , gene
S ummary . Erythrocyte levels of 5’mono‐, di‐ and triphosphates of adenosine, inosine and guanosine, together with NAD + (H) and NADP + (H) were measured before and serially after renal transplantation. The high levels of ATP and guanosine triphosphate (GTP) fell to normal within 3 d of achieving a normal plasma creatinine. The decline in ATP and GTP levels paralleled the fall in plasma creatinine. Acute graft rejection was accompanied by a rise in ATP and GTP, both of which returned rapidly to normal with resolution of the rejection episode. Radiolabelling of red cells confirmed that the metabolism of the existing red‐cell population was corrected so that observed changes in nucleotide concentrations were not due to a new cohort of cells.