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Cyclosporin A in the treatment of severe acute aplastic anaemia
Author(s) -
Jacobs Peter,
Wood Lucille,
Martell Robert W.
Publication year - 1985
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1985.tb02825.x
Subject(s) - medicine , regimen , conditioning regimen , aplastic anemia , bone marrow transplantation , gastroenterology , bone marrow , bone marrow failure , surgery , chemotherapy , pediatrics , immunology , cyclophosphamide , stem cell , haematopoiesis , biology , genetics
S ummary . Twelve consecutive adults with severe acute aplastic anaemia, not having a bone marrow transplantation option, were prospectively randomized to receive either cyclosporin A alone or an equivalent amount of this immunosuppressive agent in combination with antilymphocyte serum. The minimum follow‐up is 36 months, with half the patients developing nephrotoxicity, which was easily reversible in all but one. No response could be attributed to either regimen. Cyclosporin A does not appear to have a place as primary form of treatment for adults with severe acute aplastic anaemia, either on its own or in combination with antilymphocyte serum.