Premium
Measurement of platelet life‐span in normal subjects and patients with myeloproliferative disease with indium oxine labelled platelets
Author(s) -
Bautista A. P.,
Buckler P. W.,
Towler H. M. A.,
Dawson A. A.,
Bennett B.
Publication year - 1984
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1984.tb06115.x
Subject(s) - platelet , life span , myeloproliferative disorders , medicine , blood platelet disorders , indium , pathology , chemistry , platelet aggregation , gerontology , organic chemistry
SUMMARY The use of “‘Iridium oxine as a platelet label for the performance of platelet life‐span studies has been examined. Platelet life‐span in normal subjects varied between 8‐10 and 10‐36 d. Patients with primary thrombocythaemia had clearly reduced platelet life‐span whether or not they presented with vascular occlusion and this abnormality persisted after reduction of the platelet count to normal by busulphan therapy. Patients with similarly elevate platelet counts due to chronic granulocytic leukaemia or after splenectomy had platelet life‐span values in the normal range. Plasma β‐TG levels could not be used to predict platelet life‐span in these groups of patients. Measurement of platelet life‐span using 111 Indium labelled platelets is a useful technique in the examination of platelet function in occlusive vascular disease.