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Heat production rate in polymorphonuclear granulocytes from patients with acute myelogenous leukaemia and healthy individuals
Author(s) -
Faldt R.,
Ankerst J,
Monti M.
Publication year - 1984
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1984.tb06114.x
Subject(s) - isothermal microcalorimetry , granulocyte , medicine , immunology , production rate , chemistry , industrial engineering , physics , quantum mechanics , engineering , enthalpy
Summary Heat production rate in polymorphonuclear granulocytes (PMN) from 18 AML patients and 21 healthy individuals was measured using microcalorimetry. An increased PMN heat production rate was found in most AML patients at diagnosis and during the first 6 months of remission. In 7/7 patients showing values above the normal mean level the heat production rate decreased during sequential analysis. The increased PMN heat production rate is serum dependent and leukaemic sera induced increased calorimetric values also in PMN from healthy donors. This effect was not due to heat labile complement factors.