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Plasmodium falciparum takes up iron from transferrin
Author(s) -
Pollack Simeon,
Fleming John
Publication year - 1984
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1984.tb06087.x
Subject(s) - plasmodium falciparum , transferrin , parasite hosting , in vitro , transferrin receptor , catabolism , deferoxamine , chemistry , biology , biochemistry , malaria , metabolism , immunology , world wide web , computer science
SUMMARY Plasmodium falciparum , cultured in vitro , is inhibited by desferrioxamine, a specific iron chelating agent, despite the abundant haem iron which surrounds the parasite. In this report we show that the intraerythrocytic parasite obtains iron from transferrin. The parasite may therefore be freed of a requirement to catabolize haem to obtain iron thus minimizing haem toxicity.