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Acute myelogenous leukaemia modulated by B 12 deficiency: a case with bone marrow blast cell assay corroboration
Author(s) -
Ahmann Frederick R.,
Durie Brian G. M.
Publication year - 1984
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1984.tb06062.x
Subject(s) - bone marrow , precursor cell , medicine , haematopoiesis , bone marrow failure , in vitro , immunology , stem cell , biology , biochemistry , genetics
Summary A patient is described who appeared to demonstrate modulation of acute myelogenous leukaemia with vitamin B 12 deprivation. Support for this observation was obtained via an in vitro bone marrow blast cell assay. The addition of B 12 to this patient's bone marrow in vitro significantly stimulated the colony forming ability of the blast cells. Patients with B 12 deficiency have an increased incidence of haematopoietic malignancies and excessive replacement of B 12 may in some cases have the potential of accelerating such disorders. Intensive B 12 replacement in refractory megaloblastic anaemias should be done with caution.