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Therapy‐induced preleukaemia in patients treated for Hodgkin's lymphoma: clinical and therapeutic relevance of sequential chromosome banding studies
Author(s) -
Gyger Martin,
Forest Lorraine,
Vuong T. E.,
Perreault Claude,
Lavallee Rene,
Lacombe Michel,
Boileau Jacques,
D'Angelo Giovanni
Publication year - 1984
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1984.tb06059.x
Subject(s) - pancytopenia , cytopenia , bone marrow , medicine , lymphoma , hypoplasia , pathology , dysplasia , clinical significance , monosomy , bone marrow examination , karyotype , gastroenterology , chromosome , biology , genetics , gene
SUMMARY Between January 1978 and December 1982 successful sequential chromosome analyses were carried out on bone marrow cells of five patients previously treated for Hodgkin's lymphoma (HL) presenting unexplained cytopenia or pancytopenia during follow‐up. All patients had concurrent morphological examination of bone marrow specimens showing signs of dysplasia and/or hypoplasia, without leukaemic infiltrate. Six other patients treated for HL who had normal haematological parameters served as controls. All the patients with unexplained cytopenias had clonal chromosome abnormalities; monosomy for chromosome No. 5 was the most frequent. No abnormalities were detected in the control group. Two patients have evolved to resistant leukaemia, one died of sepsis before leukaemic conversion while severely neutropenic, and two are in full marrow and cytogenetic recovery after aggressive anti‐leukaemic treatment in the pre‐leuk‐aemic phase. Our data suggest that cytogenetic studies may be of crucial value in detecting therapy‐induced preleukaemia (t‐PL) at an early stage of its evolution and in planning appropriate therapy before the establishment of overt leukaemia.