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Ph 1 ‐positive and Ph 1 ‐negative abnormal cell lines in a child with lymphoblastic lymphoma
Author(s) -
Shikano Takaaki,
Kaneko Yasuhiko,
Ishikawa Yorikazu,
Niikawa Norio,
Tonooka Tatsuto,
Takeda Takeo,
Kikuchi Masahiro
Publication year - 1984
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1984.tb03992.x
Subject(s) - chromosomal translocation , lymphoma , bone marrow , lymphoblast , chromosome , lymphoblastic lymphoma , mediastinal mass , karyotype , pathology , peripheral blood , cell culture , microbiology and biotechnology , biology , medicine , immunology , t cell , genetics , immune system , gene
S ummary . A 7‐year‐old Japanese boy with Ph 1 ‐positive‐lymphoblastic lymphoma is described. The diagnosis was based on biopsied tonsils which were enlarged at the time of admission. On the eighth day after admission an enlarged mediastimal mass was detected on a chest X‐ray film. The lymphoblasts which appeared in the peripheral blood and bone marrow proved to be T‐cells. Chromosome studies on the bone marrow cells revealed two abnormal cell lines; one had a 7; 11 translocation and the other a 7;11 translocation and a 9;22 translocation, forming the Ph 1 ‐chromosome. The latter line with the Ph 1 chromosome was considered to have been derived from the former line without the Ph 1 . Our findings show that the Prochromosome may be a secondary change in the course of karyotypic evolution.