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Oral administration of cyclosporin A for recipients of allogeneic marrow transplants: implications of clinical gut dysfunction
Author(s) -
Atkinson K.,
Biggs J. C.,
Britton K.,
Short R.,
Mrongovius R.,
And A. Concan,
Dodds A.
Publication year - 1984
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1984.tb03950.x
Subject(s) - medicine , cyclosporins , enteritis , graft versus host disease , gastroenterology , immunology , oral administration , disease , transplantation
S ummary . Cyclosporin A (CyA) was used to minimize graft‐versus‐host disease (GVHD) in 28 recipients of allogeneic marrow transplants. When given orally, the absorption of CyA was markedly dependent on normal gut function. Patients without gut dysfunction showed normal serum concentration‐time curves while those with diarrhoea from any cause (chemo‐radiation enteritis, acute GVHD of the gut, infectious enteritis) showed minimal absorption of the drug. These data indicate the desirability of the intravenous administration of CyA during periods of gut dysfunction in marrow transplant recipients.