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Prophylactic antithrombotic therapy with stanozolol in patients with familial antithrombin III deficiency
Author(s) -
Winter J. H.,
Fenech A.,
Bennett B.,
Douglas A. S.
Publication year - 1984
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1984.tb02927.x
Subject(s) - stanozolol , medicine , antithrombotic , antithrombin , antithrombin iii deficiency , heparin , anabolism
S ummary. Three patients with familial antithrombin III deficiency underwent a trial of prophylactic antithrombotic therapy with stanozolol. An increase in plasma fibrinolytic activity and antithrombin III was seen. Acute venous thrombosis occurred in two patients; in the first patient thrombosis was precipitated by venography but in the second no precipitating factor was found. Our experience suggests that stanozolol is not a suitable prophylactic agent in patients with familial antithrombin III deficiency.