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Malignant lymphomas with band 8q24 chromosome abnormality: a morphologic continuum extending from Burkitt's to immunoblastic lymphoma
Author(s) -
Sigaux F.,
Berger R.,
Bernheim A.,
Valensi F.,
Daniel M. T.,
Flandrin G.
Publication year - 1984
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1984.tb02913.x
Subject(s) - chromosomal translocation , pathology , lymphoma , burkitt's lymphoma , histiocyte , abnormality , medicine , biology , genetics , psychiatry , gene
S ummary. Chromosome abnormality involving band 8q24 is present in the malignant cells in virtually all ‘Burkitt's’ type malignancies. t(8;14)(q24;q32) translocations have nevertheless been found in certain cases of malignant lymphomas (ML) described as ‘small non‐cleaved non‐Burkitt’, ‘immunoblastic’ or ‘histiocytic’. With a view to comparing objectively the histological picture of such lymphomas, we undertook morphometric analysis of seven cases of diffuse ML classed as ‘Burkitt's’ (three cases), ‘immunoblastic’ (two cases), ‘small non‐cleaved non‐Burkitt’ (one case) and ‘large‐cell lymphoma’ (one case), all exhibiting band 8q24 rearrangement arising from various translocations. Our study substantiates the view that the histologic picture of MLs with 8q24 anomaly fits into a morphological continuum containing ‘Burkitt's’, ‘small non‐cleaved non‐Burkitt’ and ‘immunoblastic’ lymphomas.