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Clinical and immunological study of non‐Hodgkin T‐cell lymphomas (cutaneous and lymphoblastic lymphomas excluded)
Author(s) -
Brouet JeanClaude,
Rabian Claire,
Gisselbrecht Christian,
Flandrin Georges
Publication year - 1984
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1984.tb02901.x
Subject(s) - antigen , lymphoma , pathology , lymphoblastic lymphoma , monoclonal antibody , immunology , cytotoxic t cell , phenotype , medicine , t cell , antibody , biology , immune system , in vitro , biochemistry , gene
S ummary. We present here the immunologic, morphologic and clinical features of 16 T‐derived adult non‐Hodgkin lymphomas (NHL) (lymphoblastic and cutaneous lymphomas being excluded) observed in an unselected series of 260 NHL. Malignant cells bore T cell antigens (16 cases) but formed E rosettes in 14 cases only. In nine cases studied with monoclonal antibodies to T cell antigenic subsets, the phenotype of malignant cells was homogeneous; in seven cases the cells had a clear‐cut helper or suppressor/cytotoxic phenotype; in one case cells had a cortical thymocyte phenotype. No T‐cell subset antigens were detected on malignant cells from the last patient. Prominent morphologic features were a striking variation in tumour cell sizes, vascular proliferation and admixture of a large number of macrophages; most often, those lymphomas with a diffuse growth pattern could not be easily assigned to a given NHL subtype. The course of the disease was aggressive in most patients, only four having experienced a sustained complete remission. Waldeyer's ring involvement, waxing and waning nodes, polyclonal hypergammaglobulinaemia and skin infiltrates may be distinctive clinical features in some patients.