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T‐cell acute lymphoblastic leukaemia with late developing Philadelphia chromosome
Author(s) -
Miller Barbara A.,
Reid Michael M.,
Nell Marilyn,
Lipton Jeffrey M.,
Sallan Stephen E.,
Nathan David G.,
Tantravahi Ramana
Publication year - 1984
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1984.tb01279.x
Subject(s) - chromosomal translocation , philadelphia chromosome , chromosome , cytogenetics , karyotype , chronic myelogenous leukemia , biology , long arm , acute lymphocytic leukemia , cancer research , lymphoblastic leukemia , immunology , leukemia , pathology , medicine , microbiology and biotechnology , genetics , gene
S ummary A case of childhood T‐cell acute lymphoblastic leukaemia (ALL) is presented in which the only chromosome abnormality at diagnosis was a deletion of part of the short arm of one chromosome 9 (9p − ). Cytogenetic studies at relapse showed, in addition to 9p − , a partial deletion of the long arm of one chromosome 6 (6q − ) and the Philadelphia chromosome (Ph 1 ) produced as a result of the classical translocation t(9q + ;22q − ). All metaphases from haemopoietic colonies grown from a cryopreserved specimen of this patient's marrow at relapse were normal, in contrast to haemopoietic colonies cultured from patients with chronic myelogenous leukaemia (CML) which contained the Ph 1 . A hypothesis which incorporates T‐cell ALL with late development of the Ph 1 into the overall family of Ph 1 positive diseases is suggested.