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Rhesus immunization in male volunteers: changes in lymphocyte functions following secondary immunizations in anti‐D responders and non‐responders
Author(s) -
Barclay G. R.,
Greiss M. A. M.,
McCann Moira C.,
Urbaniak S. J.
Publication year - 1983
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1983.tb07314.x
Subject(s) - antibody dependent cell mediated cytotoxicity , immunology , immunization , lymphocyte , antibody , antigen , medicine , monoclonal antibody
S ummary . After secondary immunizations of rhesus(D)‐negative male volunteers with Rh(D)‐positive red cells, changes were found in the in vitro transformation and antibody‐dependent cell‐mediated cytotoxicity (ADCC) capacities of the volunteers’ lymphocytes. Responders, who produced anti‐D, showed marked depressions of ADCC which were not found in non‐responders. Responders and non‐responders in general showed similar changes in lymphocyte transformation. The relationships between altered lymphocyte functions following immunization, immunoregulatory activity and responsiveness to the Rh(D) antigen are discussed.