Premium
The peroxidase activity and cellular content of granule proteins in PMN during pregnancy
Author(s) -
ÖBerg G.,
Lindmark G.,
Moberg L.,
Venge P.
Publication year - 1983
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1983.tb02853.x
Subject(s) - lactoferrin , peroxidase , eosinophil granule proteins , myeloperoxidase , eosinophil cationic protein , pregnancy , chemistry , chemiluminescence , eosinophil , eosinophil peroxidase , andrology , biochemistry , immunology , microbiology and biotechnology , enzyme , medicine , biology , inflammation , asthma , chromatography , genetics
S ummary. The cellular content of myeloperoxidase (MPO), chymotrypsin‐like cationic protein (CCP) and lactoferrin (LF) of isolated polymorphonuclear leucocytes (PMNs) from pregnant women were analysed by immuno‐chemical methods. The cellular levels of MPO and CCP were unaltered during prenancy while the cellular levels of LF were increased during pregnancy and post partum ( P <0·01). Peroxidase activity within isolated PMN was analysed by two methods, a Guaiacol method and a Chemiluminescence method. The activity was found to be reduced during pregnancy. The reduction was explained by the reduction in eosinophil peroxidase which in turn was a consequence of a reduced number of circulating eosinophils during pregnancy.