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Effect of alpha thalassaemia on the rheology of homozygous sickle cell disease
Author(s) -
Serjeant B. E.,
Mason K. P.,
Kenny M. W.,
Stuart J.,
Higgs D. R.,
Weatherall D. J.,
Hayes R. J.,
Serjeant G. R.
Publication year - 1983
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1983.tb02163.x
Subject(s) - blood viscosity , hemoglobinopathy , sickle cell anemia , rheology , erythrocyte deformability , medicine , disease , plasma viscosity , hemoglobin s , hemorheology , thalassemia , immunology , red blood cell , chemistry , materials science , composite material
S ummary . A study of rheological determinants (plasma viscosity, whole‐blood viscosity, and erythrocyte deformability) was made in 24 matched pairs of patients with homozygous sickle cell disease, with and without homozygous α‐thalassaemia 2. Patients with coexisting α‐thalassaemia showed a significant increase in erythrocyte deformability measured as filtration of washed erythrocytes through 5 μm diameter pores and also as viscosity of whole blood at high shear rate (230 s −1 ) and standard haematocrit (0·45). This rheological advantage may explain the beneficial effect of α‐thalassaemia 2 on haematological parameters and clinical events in homozygous sickle cell disease.