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Factor VIII inhibitor and raised platelet IgG levels associated with methyldopa therapy
Author(s) -
Devereux S.,
Fisher D. M.,
Roter B. L. T.,
Hegde U. M.
Publication year - 1983
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1983.tb02123.x
Subject(s) - platelet , antibody , coagulation , medicine , immunology , methyldopa , pharmacology , gastroenterology , blood pressure
S ummary . An inhibitor to the plasma coagulation factor VIII and abnormally high levels of platelet associated IgG (PAIgG) were found in a patient whilst on methyldopa. Both these parameters fell on initial withdrawal, but on rechallenge with the drug only the PAIgG rose to the high presenting levels. No inhibitory activity to factor VIIIc could be detected in a concentrated eluate prepared from the patient's platelets. These results may imply that two distinct antibodies were provoked by the administration of methyldopa, but could also be explained by the action of anti VIIIc alone on the patient's platelets.