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Transplantation of bone marrow fibroblastoid stromal cells in mice via the intravenous route
Author(s) -
Piersma A. H.,
Ploemacher R. E.,
Brockbank K. G. M.
Publication year - 1983
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1983.tb02097.x
Subject(s) - stromal cell , bone marrow transplantation , bone marrow , medicine , transplantation , pathology , cancer research
S ummary . Kinetics of fibroblastic colony‐forming cells (CFU‐F) were studied in mouse bone marrow after lethal total body irradiation and intravenous bone marrow transplantation. After an initial decrease, CFU‐F numbers recovered, and plateaued 5 weeks post‐treatment at 10% of normal values. Using chromosome‐marked donor bone marrow cells we found that 1 day after transplantation 72% of donor CFU‐F had reached the recipient's bone marrow, indicating a highly specific lodgment of CFU‐F. Three months after transplantation donor CFU‐F were still detectable and comprised about half of the femoral CFU‐F population. It is concluded that CFU‐F, a component of the haemopoietic microenvironment, are transplantable via the intravenous route.