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Penicillin‐G degradation products inhibit in vitro granulopoiesis
Author(s) -
Neftel Klaus A.,
Müller Marianne R.,
Wälti Manfred,
Erni Jana,
Gugler Madeleine,
Arrenbrecht Stefan
Publication year - 1983
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1983.tb02093.x
Subject(s) - granulopoiesis , penicillin , in vivo , in vitro , cytotoxicity , chemistry , microbiology and biotechnology , bone marrow , antibiotics , pharmacology , stem cell , medicine , immunology , biochemistry , biology , haematopoiesis
S ummary . 38% of penicillin‐G in solution decays at 20°C within 24 h, 50% at 37°C and 66% within 3 h at 56°C. These degraded penicillin‐G solutions strongly inhibit growth and maturation of granulocytic stem cells in vitro. Inhibitory concentrations are in the range obtainable with high dose penicillin therapy in vivo. No cytotoxicity of degraded penicillin solutions on bone marrow cells was seen over 24 h. It is suggested that penicillin‐G degradation products are responsible for severe granulo‐cytopenia observed after high dose penicillin‐G therapy.