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Rapid proteolysis of unstable globins in human bone marrow
Author(s) -
Vissers Margret C.M.,
Winterbourn Christine C.,
Carrell Robin W.
Publication year - 1983
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1983.tb02042.x
Subject(s) - proteolysis , bone marrow , globin , human bone , hematology , medicine , chemistry , biology , microbiology and biotechnology , immunology , pathology , hemoglobin , biochemistry , enzyme , in vitro
S ummary . To determine whether human red cells contain a proteolytic system capable of rapidly degrading unstable proteins, the fate of pulse‐labelled puromycyl polypeptides was investigated. In erythroid bone marrow cells these unstable polypeptides were degraded to TCA‐soluble fragments with a mean half‐life of 4–5 min. However, in peripheral blood reticulotyes no proteolysis was observed, indicating that this activity declines as the red cell matures.