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Irreversible spectrin‐haemoglobin crosslinking in vivo: a marker for red cell senescence
Author(s) -
Snyder L. M.,
Leb L.,
Piotrowski J.,
Sauberman N.,
Liu S. C.,
Fortier N. L.
Publication year - 1983
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1983.tb02038.x
Subject(s) - spectrin , percoll , in vivo , cytoskeleton , red cell , senescence , red blood cell , chemistry , cell , microbiology and biotechnology , biology , biochemistry , in vitro , medicine , genetics
S ummary . We have demonstrated that the in vivo presence of spectrin and haemoglobin aggregates occur in the oldest, dehydrated and most dense fraction of normal circulating red cells, following their separation by Percoll/hypaque density gradient. To our knowledge, this is the first evidence of irreducible in vivo oxidative damage to the red cell membrane cytoskeleton.
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