Premium
The effect of malonyldialdehyde, a product of lipid peroxidation, on the deformability, dehydration and 51 Cr‐survival of erythrocytes
Author(s) -
Jain Sushil K.,
Mohandas Narla,
Clark Margaret R.,
Shohet Stephen B.
Publication year - 1983
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1983.tb02018.x
Subject(s) - lipid peroxidation , chemistry , in vivo , biochemistry , erythrocyte membrane , red blood cell , membrane fluidity , membrane , oxidative stress , biology , microbiology and biotechnology
S ummary . Erythrocyte membrane lipid peroxidation has been reported to occur in various haemolytic anaemias. In the present study, treatment of human erythrocytes with malonyldialdehyde (MDA). a product of fatty acid peroxidation, induced membrane rigidity, cellular dehydration and reduced whole cell deformability. These effects of MDA were blocked by histamine and fluorescamine, which can act as alternate substrates for MDA. Additionally, reduced deformability of MDA‐treated rabbit cells was associated with shortened 51 Cr survival in vivo. These findings suggest a biochemical basis for decreased survival of erythrocytes undergoing peroxidative damage of the membrane.