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Regeneration of peripheral blood cells following ABO incompatible allogeneic bone marrow transplantation for severe aplastic anaemia
Author(s) -
Hows J. M.,
Chipping P.M.,
Palmer S.,
GordonSmith E. C
Publication year - 1983
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1983.tb01996.x
Subject(s) - abo blood group system , medicine , platelet , bone marrow , peripheral blood , reticulocyte , immunology , aplastic anemia , gastroenterology , biology , biochemistry , messenger rna , gene
S ummary . The regeneration of peripheral blood cells in six patients receiving ABO incompatible bone marrow transplants for severe aplastic anaemia has been studied. The results are compared with those of 18 similar aplastic patients treated with ABO compatible transplants. Reticulocyte recovery in the ABO incompatible cases was significantly delayed ( P < 0·01) and associated with greatly prolonged red cell transfusion requirements ( P < 0·01). Peripheral blood regeneration of neutrophils, lymphocytes and platelets was also significantly delayed ( P < 0·01). Platelet support was required for longer in the ABO incompatible cases ( P < 0·01) but there was no increase in the incidence or severity of infections in the post transplant period.