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Granulocyte function in untreated pernicious anaemia
Author(s) -
Kätkä K.,
Skger R. A.,
Matsunaga T.,
Toivanen Auli,
Hitzig W. H.
Publication year - 1983
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1983.tb01982.x
Subject(s) - phagocytosis , granulocyte , pernicious anaemia , nitroblue tetrazolium , immunology , medicine
S ummary . Neutrophil granulocyte functions were evaluated in nine patients with pernicious anaemia (PA). Membrane potential, oxygen consumption, nitroblue tetrozolium reduction, and phagocytosis and killing of staphylococci were determined prior to the institution of vitamin B 12 therapy. There were no significant alterations in these granulocyte functions as compared with normal controls, although in several patients low values were seen. We conclude that in PA the oxidative metabolism and microbicidal functions of granulocytes in general are normal, even in severely anaemic patients.