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Impaired chemiluminescence and bactericidal killing by neutrophils from patients with severe cobalamin deficiency
Author(s) -
Skacel P.O.,
Chanarin I.
Publication year - 1983
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1983.tb01240.x
Subject(s) - cobalamin , chemiluminescence , intracellular , neutrophile , medicine , phagocytosis , immunology , granulocyte , luminol , chemistry , vitamin b12 , biochemistry , inflammation , organic chemistry
S ummary . Neutrophil function was examined in 24 patients with megaloblastic haemopoiesis due to vitamin B 12 ‐or folate deficiency. Defective bactericidal activity was demonstrated in the B 12 ‐deficient group only and was associated with normal phagocytic activity but impaired intracellular killing. Luminol amplified luminescence was consistently low in B 12 ‐deficient subjects with RBC counts of less than 2 × 10 12 /1. These defects were not seen in the folate‐deficient cases although isolated abnormalities were present in those who were also alcoholic.